abstract：OBJECTIVE:To summarize the latest information on the relationship between genes and common forms of obesity, and to review genetic markers (SNPs and miRNA) that play a role in predisposing to common forms of obesity and related disorders. MATERIALS AND METHODS:We searched PubMed with the following keywords: (obesity[T...

journal_title：European review for medical and pharmacological sciences

authors： Vettori A,Pompucci G,Paolini B,Del Ciondolo I,Bressan S,Dundar M,Kenanoğlu S,Unfer V,Bertelli M,Geneob Project.

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate whether circ-VANGL1 can promote the progression of osteoporosis (OP) by absorbing miRNA-217 to regulate RUNX2 expression. PATIENTS AND METHODS:The serum levels of circ-VANGL1, miRNA-217 and RUNX2 in OP patients and non-OP patients were detected by quantitative Real Time-Polymer...

journal_title：European review for medical and pharmacological sciences

authors： Yang L,Zeng Z,Kang N,Yang JC,Wei X,Hai Y

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore the regulatory role of lncRNA 00152 and JAK2/STAT3 pathway in the pathogenesis of hepatocellular carcinoma (HCC), and to investigate the possible underlying mechanism. PATIENTS AND METHODS:Expression levels of lncRNA 00152 in HCC tissues, matched para-cancerous tissues an...

journal_title：European review for medical and pharmacological sciences

authors： Li SJ,Sui MH,Sun ZX,Zhang WW

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To elucidate whether microRNA-374b could participate in the development of lung cancer (LC) through downregulating PTEN (gene of phosphate and tensin homolog deleted on chromosome ten) expression via activating PI3K/Akt pathway. PATIENTS AND METHODS:Expression levels of microRNA-374b and PTEN in LC tissues a...

journal_title：European review for medical and pharmacological sciences

authors： Li J,Zhou Z,Xu FC,Li J,Zeng D,Cao XQ,Han Y

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Deregulated expression of miRNAs contributes to the development of acute myeloid leukemia (AML). miR-504-3p, one of these miRNAs, has been found have upregulated expression in various human malignancies. Our present study aimed to detect the expression of miR-504-3p and its biological effect in AML. PATIENTS...

journal_title：European review for medical and pharmacological sciences

authors： Li SM,Zhao YQ,Hao YL,Liang YY

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Neoplastic disease is frequently associated with poor nutritional status or severe malnutrition. Diet and nutritional intervention are becoming increasingly important for prognosis and quality of life in cancer patients. Accessible and repeatable tools for assessing nutritional status with body composition te...

journal_title：European review for medical and pharmacological sciences

authors： Di Renzo L,Marchetti M,Cioccoloni G,Gratteri S,Capria G,Romano L,Soldati L,Mele MC,Merra G,Cintoni M,De Lorenzo A

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:In the last decades, several cognitive-enhancing drugs have been sold onto the drug market. Methylphenidate and analogs represent a sub-class of these new psychoactive substances (NPS). We aimed to review the use and misuse of methylphenidate and analogs, and the risk associated. Moreover, we exhaustively rev...

journal_title：European review for medical and pharmacological sciences

authors： Carlier J,Giorgetti R,Varì MR,Pirani F,Ricci G,Busardò FP

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of miR-32-5p on the biological behaviors of cervical cancer (CCa), the relevant mechanism was studied in CCa cell lines (HeLa) in vitro. PATIENTS AND METHODS:The expression level of miR-32-5p was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Ta...

journal_title：European review for medical and pharmacological sciences

authors： Liu YJ,Zhou HG,Chen LH,Qu DC,Wang CJ,Xia ZY,Zheng JH

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:MicroRNA-610 (miR-610) functions as a tumor suppressor in various types of cancers. However, whether miR-610 acted as a functional miRNA in oral squamous cell carcinoma (OSCC) is still largely unknown. The current study was designed to explore the expression pattern and function of miR-610 in OSCC and to inve...

journal_title：European review for medical and pharmacological sciences

authors： Yao LX,Liu J,Xu L

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To investigate the correlation between the acute myocardial infarction (AMI) complicated with cerebral infarction (CI) and expression levels of matrix metalloproteinase-2 (MMP-2) and MMP-9. PATIENTS AND METHODS:A total of 50 AMI patients treated in our hospital were enrolled, including 23 AMI patients compli...

journal_title：European review for medical and pharmacological sciences

authors： Zhou L,Kou DQ

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Age-related macular degeneration (AMD) is mainly characterized by dysfunction of retinal pigment epithelium (RPE) cells. This study aimed to investigate the protective effects of resveratrol on oxidative damaged RPE cells. MATERIALS AND METHODS:Human D407 cells were divided into normal control (NC), H2O2 tre...

journal_title：European review for medical and pharmacological sciences

authors： Yang Y,Wu ZZ,Cheng YL,Lin W,Qu C

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to explore the mechanism of micro-ribonucleic acid (miR)-214-3p in regulating fracture healing in rats with osteoporosis. MATERIALS AND METHODS:A total of 30 female Sprague-Dawley rats were selected and randomly divided into 3 groups, including group A [phosphate-buffered saline...

journal_title：European review for medical and pharmacological sciences

authors： Zhou LG,Shi P,Sun YJ,Liu HZ,Ni JQ,Wang X

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the inhibitory role of microRNA-1299 (miR-1299) in prostate cancer, and to explore the possible underlying mechanism. PATIENTS AND METHODS:The expression of miR-1299 in 35 PCa tissues and para-carcinoma tissues, as well as PCa cell lines (PC-3) and prostatic epithelia...

journal_title：European review for medical and pharmacological sciences

authors： Zhang FB,Du Y,Tian Y,Ji ZG,Yang PQ

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Mounting evidence has suggested that microRNAs (miRNAs) play crucial roles in the progression of nasopharyngeal carcinoma (NPC). However, the molecular mechanism remains not fully understood. We aimed to examine the expression and biological function of miR-122-5p in NPC. MATERIALS AND METHODS:Quantitative R...

journal_title：European review for medical and pharmacological sciences

authors： Liu YH,Liu JL,Wang Z,Zhu XH,Chen XB,Wang MQ

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:This study investigates whether microRNA-599 can inhibit the progression of Parkinson's disease (PD) by regulating the LRRK2 expression. We aim to search for a new therapeutic target for PD. MATERIALS AND METHODS:A mouse model of PD was first established. A relative amount of TH+ neurons in the mouse brain w...

journal_title：European review for medical and pharmacological sciences

authors： Wu Q,Xi DZ,Wang YH

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To explore the influence of micro ribonucleic acid (miR)-154 on myocardial apoptosis in rats with acute myocardial infarction (AMI), and to analyze whether Wnt/β-catenin signaling pathway was involved in the regulation. MATERIALS AND METHODS:The Sprague-Dawley (SD) rat model of AMI was established via ligati...

journal_title：European review for medical and pharmacological sciences

authors： Sun HY,Wang XL,Ma LC,Yang M,Yang HJ,Huang HW,Zhao GA

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To explore whether lncRNA GIHCG participates in the pathogenic progression of ovarian cancer (OC) and its underlying mechanism. PATIENTS AND METHODS:Expression levels of GIHCG and microRNA-429 in 30 OC tissues and normal ovarian tissues were detected by quantitative Real time-polymerase chain reaction (qRT-P...

journal_title：European review for medical and pharmacological sciences

authors： Yao N,Yu L,Zhu B,Gan HY,Guo BQ

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to characterize the effect of Twist2 on epithelial-to-mesenchymal transition (EMT) and the invasive potential of colorectal cancer (CRC) cells and to explore the mechanisms underlying the regulative effect of Twist1 and Twist2 on matrix metalloproteinase 2 (MMP2) expression in CRC. PATIENTS ...

journal_title：European review for medical and pharmacological sciences

authors： Lu K,Dong JL,Fan WJ

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To identify the potential role of miR-490-3p in the development of esophageal squamous cell carcinoma (ESCC), and to explore the possible underlying mechanism. PATIENTS AND METHODS:Human ESCC tissues and cancer-adjacent normal tissues were collected. The mRNA expression level of miR-490-3p was detected by qu...

journal_title：European review for medical and pharmacological sciences

authors： Kang NN,Ge SL,Zhang RQ,Huang YL,Liu SD,Wu KM

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore whether miR-650 could inhibit the proliferation of glioma by regulating FAM83F and to investigate the specific role of miR-650 in glioma occurrence. PATIENTS AND METHODS:The expression of FAM83F in tumor or para-cancerous tissues of 24 glioma patients was detected by quan...

journal_title：European review for medical and pharmacological sciences

authors： Xu L,Yu QW,Fang SQ,Zheng YK,Qi JC

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:This is a pilot study to evaluate the effectiveness of concomitant administration of hyaluronic acid and topical hyperbaric oxygen therapy (THOT) by a specifically designed medical device (vaginal natural oxygenation device, VNOD) in improving the symptomatology of postmenopausal patients with vulvo-vaginal a...

journal_title：European review for medical and pharmacological sciences

authors： Condemi L,Di Giuseppe J,Delli Carpini G,Garoia F,Frega A,Ciavattini A

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of highly-expressed FOSL1 on the tumorigenesis and metastasis of prostate cancer. PATIENTS AND METHODS:Researches were carried out in human prostate cancer tissues and cell lines. In prostate cancer tissues, the expression of FOSL was detected by immunohistochemistry. In vitro cell ...

journal_title：European review for medical and pharmacological sciences

authors： Luo YZ,He P,Qiu MX

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:This study was made to investigate and evaluate the safety and carcinogenicity of nitenpyram (NIT) in rats. MATERIALS AND METHODS:A totally 50 male and 50 female SD rats were treated with NIT at 0, 800, 2400, and 7200 ppm, respectively, for 104 w. The growth, clinical signs, and survival rates, as well as th...

journal_title：European review for medical and pharmacological sciences

authors： Xing LG,Wu YL,Zheng HN,Jia YY,Wu GF,Yang C

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the relationship between micro ribonucleic acid (miR)-152-3p and chronic myeloid leukemia (CML), and to explore the underlying mechanism. PATIENTS AND METHODS:The expression level of miR-152-3p in the bone marrow of 40 CML patients and 30 normal controls was detected ...

journal_title：European review for medical and pharmacological sciences

authors： Wang L,Wang Y,Lin J

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To investigate the role of IL-9 in chronic obstructive pulmonary disease (COPD), and to explore its potential mechanism. MATERIALS AND METHODS:A mouse COPD model was established by exposure to cigarette smoke. COPD mice were then randomly assigned into two groups, including: the PBS group and the IL-9 antibo...

journal_title：European review for medical and pharmacological sciences

authors： Zou SC,Pang LL,Mao QS,Wu SY,Xiao QF

更新日期：2018-12-01 00:00:00

abstract：CASE REPORT:We reported a HIV-infected patient, diagnosed as PJP with G6PD deficiency. Pneumocystis jiroveci pneumonia (PJP) is the most common opportunistic infection in subjects with human immunodeficiency virus (HIV) infection. Trimethoprim-sulfamethoxazole (TMP-SMX) is the first line regimen for Pneumocystis jirove...

journal_title：European review for medical and pharmacological sciences

authors： Chang HC,Yang WT,Chen TC

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Although Tantalum (Ta) exhibits better osteoinductivity in healthy subjects when compared with titanium (Ti), the relative effects in osteoporosis remain unknown. MATERIALS AND METHODS:In this study, bone mesenchymal stromal cells of ovariectomized rats (OVX-rBMSCs) were seeded on Ta and Ti substrates for in...

journal_title：European review for medical and pharmacological sciences

authors： Lu MM,Wu PS,Guo XJ,Yin LL,Cao HL,Zou D

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to identify the role of long non-coding RNA PVT1 (lnc-PVT1) in the progression of ovarian cancer. PATIENTS AND METHODS:The expression of lnc-PVT1 in ovarian cancer cells and 50 paired tissue samples were detected by quantitative Reverse Transcriptase-Polymerase Chain Reaction (qRT-P...

journal_title：European review for medical and pharmacological sciences

authors： Zou MF,Ling J,Wu QY,Zhang CX

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Emerging evidence has suggested that dysregulation of miR-874-3p may be involved in tumor development and progression in various types of cancers. However, its expression and biological function in esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to explore the roles of miR...

journal_title：European review for medical and pharmacological sciences

authors： Yuan RB,Zhang SH,He Y,Zhang XY,Zhang YB

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To explore the possible role and mechanism of miR-497 in cutaneous squamous cell carcinoma. PATIENTS AND METHODS:Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to detect miR-497 and FAM114A2 expression level in 38 cases of cutaneous squamous cell carcinoma (CSCC) and 22 normal skin tissu...

journal_title：European review for medical and pharmacological sciences

authors： Wei XH,Gu XL,Zhou XT,Ma M,Lou CX

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore the role of HOTAIR in inflammatory response after acute myocardium infarction (AMI) and to investigate its underlying mechanism. MATERIALS AND METHODS:The AMI model was first constructed in rats, and heart tissues were harvested. Expression levels of HOTAIR and receptor o...

journal_title：European review for medical and pharmacological sciences

authors： Lu W,Zhu L,Ruan ZB,Wang MX,Ren Y,Li W

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To explore the protective role of Vitamin D Receptor (VDR) in retinal ganglion cells (RGCs) after high-level glucose induction, and to investigate its underlying mechanism. MATERIALS AND METHODS:Primary RGCs were isolated from 24-hour-old Sprague Dawley (SD) rats and cultured in 50 mmol/L glucose. The expres...

journal_title：European review for medical and pharmacological sciences

authors： Lei XJ,Xu YL,Yang YQ,Bing YW,Zhao YX

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to explore the role of lncRNA ZNF667-AS1 in the recovery of spinal cord injury (SCI), and to investigate its underlying mechanism. MATERIALS AND METHODS:Mice were randomly assigned to the SCI group, the sham group and the lncRNA ZNF667-AS1 group, with 10 mice in each group. With Inf...

journal_title：European review for medical and pharmacological sciences

authors： Li JW,Kuang Y,Chen L,Wang JF

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To investigate the regulating roles of miR-199b in hepatocellular carcinoma (HCC). PATIENTS AND METHODS:The expression of miR-199b of 45 human HCC tissues and the corresponding para-cancerous tissue samples were detected by quantitative Real-time-polymerase chain reaction (qRT-PCR). Western blot was employed...

journal_title：European review for medical and pharmacological sciences

authors： Li GL,Yuan JH,Zhuang GD,Wu DQ

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To elucidate the biological functions of long non-coding RNA (lncRNA) SNHG7 in breast cancer (BC), and its underlying mechanism in the occurrence and progression of BC. PATIENTS AND METHODS:The expression of SNHG7 in 72 pairs of BC tissues and paracancerous tissues was detected by quantitative Real-time poly...

journal_title：European review for medical and pharmacological sciences

authors： Luo X,Song Y,Tang L,Sun DH,Ji DG

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To explore whether miR-216a-3p could promote differentiation of bone marrow mesenchymal stem cells (BMMSCs) into type II alveolar epithelial cells (ACE II) via Wnt/β-catenin pathway, thereby alleviating neonatal respiratory distress syndrome (NRDS). MATERIALS AND METHODS:BMMSCs were directionally differentia...

journal_title：European review for medical and pharmacological sciences

authors： Song H,Lu HN,Chen X,Jiang XF,Yang Y,Feng J

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate the influences of micro ribonucleic acid (miR)-21 and downstream Toll-like receptor 4 (TLR4)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway on myocardial apoptosis induced by myocardial ischemia-reperfusion (I/R) injury in rats. MATERIAL...

journal_title：European review for medical and pharmacological sciences

authors： Pan YQ,Li J,Li XW,Li YC,Li J,Lin JF

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to explore whether histamine H3 receptor antagonist Clobenpropit could protect propofol-induced neurotoxicity in hippocampal neurons. MATERIALS AND METHODS:Hippocampal neurons were extracted from neonatal rats and induced with propofol. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl ...

journal_title：European review for medical and pharmacological sciences

authors： He W,Yuan QH,Zhou Q

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Pathogenesis factor of pregnant hypertension is still unclear and lacks of effective treatment. MiR-155 is a recently discovered miRNA molecule with differential expression in pregnant hypertension, which participates in the disease regulation. As a downstream target gene of miR-155, FOXO3a is correlated with...

journal_title：European review for medical and pharmacological sciences

authors： Liu DF,Li SM,Zhu QX,Jiang W

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To explore the effects of interventional therapy on human immunodeficiency virus (HIV)-1 Tat interactive protein 2/Tat interactive protein 30 (HTATIP2/TIP30), B7-H4 and short-term curative effect in primary hepatocellular carcinoma. PATIENTS AND METHODS:62 patients with primary hepatocellular carcinoma admit...

journal_title：European review for medical and pharmacological sciences

authors： Zheng ZJ,Fu J,Zhi F,Liu WJ,Guo YJ,Zhu DD,Mo JG

更新日期：2018-10-01 00:00:00